Analysis of the Variability of the Pharmacokinetics of the Long Half-Life Drug Amiodarone in Bioequivalence Studies

The article provides an extensive analysis of the data obtained in bioequivalence studies, which can be considered for further evaluation development general and individual therapeutic regimens. Concrete two studies compared amiodarone formulations included plasma levels active metabolite desethylamiodarone. mean variability concentrations pharmacokinetic parameters. In addition, a global structural meta-analysis level sets was performed. half-life not well defined total area below curves less appropriate estimating bioequivalence.